Dataset Information

Molecular mechanisms underlying AMH elevation in hyperoestrogenic states in males.

ABSTRACT: Anti-Müllerian hormone (AMH) is secreted by Sertoli cells of the testes from early fetal life until puberty, when it is downregulated by androgens. In conditions like complete androgen insensitivity syndrome (CAIS), AMH downregulation does not occur and AMH increases at puberty, due in part to follicle-stimulating hormone (FSH) effect. However, other conditions like Peutz-Jeghers syndrome (PJS), characterised by low FSH, also have increased AMH. Because both CAIS and PJS may present as hyperoestrogenic states, we tested the hypothesis that oestradiol (E2) upregulates AMH expression in peripubertal Sertoli cells and explored the molecular mechanisms potentially involved. The results showed that E2 is capable of inducing an upregulation of endogenous AMH and of the AMH promoter activity in the prepubertal Sertoli cell line SMAT1, signalling through ER? binding to a specific ERE sequence present on the hAMH promoter. A modest action was also mediated through the membrane oestrogen receptor GPER. Additionally, the existence of ER? expression in Sertoli cells in patients with CAIS was confirmed by immunohistochemistry. The evidence presented here provides biological plausibility to the hypothesis that testicular AMH production increases in clinical conditions in response to elevated oestrogen levels.

SUBMITTER: Valeri C

PROVIDER: S-EPMC7492256 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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Molecular mechanisms underlying AMH elevation in hyperoestrogenic states in males.

Valeri Clara C Lovaisa María M MM Racine Chrystèle C Edelsztein Nadia Y NY Riggio Marina M Giulianelli Sebastián S Venara Marcela M Bedecarrás Patricia P Ballerini María G MG di Clemente Nathalie N Lamb Caroline A CA Schteingart Helena F HF Rey Rodolfo A RA

Scientific reports 20200915 1

Anti-Müllerian hormone (AMH) is secreted by Sertoli cells of the testes from early fetal life until puberty, when it is downregulated by androgens. In conditions like complete androgen insensitivity syndrome (CAIS), AMH downregulation does not occur and AMH increases at puberty, due in part to follicle-stimulating hormone (FSH) effect. However, other conditions like Peutz-Jeghers syndrome (PJS), characterised by low FSH, also have increased AMH. Because both CAIS and PJS may present as hyperoest ...[more]

PMID: 32934281

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Dataset Information

Molecular mechanisms underlying AMH elevation in hyperoestrogenic states in males.

Publications

Molecular mechanisms underlying AMH elevation in hyperoestrogenic states in males.

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