Ontology highlight
ABSTRACT:
SUBMITTER: Sakuragi M
PROVIDER: S-EPMC7493194 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
ChemistryOpen 20200916 9
The penetration mechanism of choline chloride-glycerol deep eutectic solvent (DES) through the stratum corneum (SC) as a potential solvent for a novel enhancer of protein penetration into the skin was investigated in a wide and small angle X-ray diffraction study. We found that DES penetrated through intercellular lipids but not the corneocytes. DES seemed to extract a portion of lipids of the short lamellae in the SC. Hydrated DES with a DES to water weight ratio of 9 to 1 (9DES-1H<sub>2</sub>O ...[more]