Complex Mixtures of Chlorinated Paraffins Found in Hand Wipes of a Norwegian Cohort.

ABSTRACT: Up to 18000 ng of total chlorinated paraffins (CPs) was found in hand wipes of individual adult participants in a Norwegian cohort study (n = 60), with a geometric mean (SD) value of 870 (2700) ng. The CPs covered a wide range of alkane chain lengths from C7 to C48 with variable chlorine substitution. Complex mixtures of very-short-chain (vSCCPs, C<10), short-chain (SCCPs, C10-13), medium-chain (MCCPs, C14-17), and long-chain (LCCPs, C>17) CPs were found, contributing on average 0.3%, 20%, 58%, and 22%, respectively, of the total CPs. Significant positive correlations were found between CP levels and factors related to the indoor environment and product use, including living in a house/apartment built before the ban of SCCPs, having a sofa, the number of TVs in the home, and owning a car, which mirrors CP usage as flame retardants and/or plasticizers in consumer products. Compared to previous studies of other organic contaminants in hand wipe samples from the same cohort, CPs were the most abundant flame retardants. This is the first report of CPs in hand wipes, and dermal exposure based on these data suggested that hand contact could be an important human exposure pathway for LCCPs.

SUBMITTER: Yuan B 

PROVIDER: S-EPMC7493225 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature