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MS-Derived Isotopic Fine Structure Reveals Forazoline A as a Thioketone-Containing Marine-Derived Natural Product.

ABSTRACT: Forazoline A is a structurally complex PKS-NRPS hybrid produced by marine-derived Actinomadura sp. During the course of studies highlighting the application of IFS analysis as a powerful tool for natural products analysis, we were alerted to an earlier misinterpretation with respect to forazoline A structure elucidation. In particular, IFS reveals that forazoline A contains a thioketone moiety rarely seen in secondary metabolites and, thus, constitutes an even more intriguing structure than originally thought.

SUBMITTER: Zhang F

PROVIDER: S-EPMC7494057 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

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MS-Derived Isotopic Fine Structure Reveals Forazoline A as a Thioketone-Containing Marine-Derived Natural Product.

Zhang Fan F Wyche Thomas P TP Zhu Yanlong Y Braun Doug R DR Yan Jia-Xuan JX Chanana Shaurya S Ge Ying Y Guzei Ilia A IA Chevrette Marc G MG Currie Cameron R CR Thomas Michael G MG Rajski Scott R SR Bugni Tim S TS

Organic letters 20200204 4

Forazoline A is a structurally complex PKS-NRPS hybrid produced by marine-derived <i>Actinomadura</i> sp. During the course of studies highlighting the application of IFS analysis as a powerful tool for natural products analysis, we were alerted to an earlier misinterpretation with respect to forazoline A structure elucidation. In particular, IFS reveals that forazoline A contains a thioketone moiety rarely seen in secondary metabolites and, thus, constitutes an even more intriguing structure th ...[more]

PMID: 32017574

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