Ontology highlight
ABSTRACT:
SUBMITTER: Yu Z
PROVIDER: S-EPMC7494387 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Yu Zhen Z Li Xundou X Duan Jinhong J Yang Xian-Da XD
International journal of nanomedicine 20200911
<h4>Purpose</h4>Chemotherapy of colon cancer needs improvement to mitigate the severe adverse effects (AEs) associated with the cytotoxic drugs. The aim of this study is to develop a novel targeted drug delivery system (TDDS) with practical application potential for colon cancer treatment.<h4>Methods</h4>The TDDS was built by loading docetaxel (DTX) in albumin nanoparticles (NPs) that were functionalized with nucleolin-targeted aptamers (AS1411).<h4>Results</h4>The TDDS (Apt-NPs-DTX) had an aver ...[more]