Drainage of amniotic fluid delays vocal fold separation and induces load-related vocal fold mucosa remodeling.

ABSTRACT: In the present study, we investigated the role of mechanical load as generated by amniotic fluid in the vocal fold embryogenesis. In utero, amniotic fluid flows through the laryngeal inlet down into the lungs during fetal breathing and swallowing. In a mouse model, the onset of fetal breathing coincides with epithelial lamina recanalization. The epithelial lamina is a temporal structure that is formed during early stages of the larynx development and is gradually resorbed whereby joining the upper and lower airways. Here, we show that a temporary decrease in mechanical load secondary to drainage of amniotic fluid and subsequent flow restoration, impaired timing of epithelial lamina disintegration. Moreover, re-accumulation of fluid in the laryngeal region led to VF tissue deformation trigg

SUBMITTER: Lungova V 

PROVIDER: S-EPMC7494656 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature