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A membrane transporter determines the spectrum of activity of a potent platinum-acridine hybrid anticancer agent.

ABSTRACT: Cytotoxic drugs that are mechanistically distinct from current chemotherapies are attractive components of personalized combination regimens for combatting aggressive forms of cancer. To gain insight into the cellular mechanism of a potent platinum-acridine anticancer agent (compound 1), a correlation analysis of NCI-60 compound screening results and gene expression profiles was performed. A plasma membrane transporter, the solute carrier (SLC) human multidrug and toxin extrusion protein 1 (hMATE1, SLC47A1), emerged as the dominant predictor of cancer cell chemosensitivity to the hybrid agent (Pearson correlation analysis, p?

SUBMITTER: Yao X

PROVIDER: S-EPMC7494928 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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A membrane transporter determines the spectrum of activity of a potent platinum-acridine hybrid anticancer agent.

Yao Xiyuan X Watkins Noah H NH Brown-Harding Heather H Bierbach Ulrich U

Scientific reports 20200916 1

Cytotoxic drugs that are mechanistically distinct from current chemotherapies are attractive components of personalized combination regimens for combatting aggressive forms of cancer. To gain insight into the cellular mechanism of a potent platinum-acridine anticancer agent (compound 1), a correlation analysis of NCI-60 compound screening results and gene expression profiles was performed. A plasma membrane transporter, the solute carrier (SLC) human multidrug and toxin extrusion protein 1 (hMAT ...[more]

PMID: 32939009

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