Ontology highlight
ABSTRACT:
SUBMITTER: Tsukamoto H
PROVIDER: S-EPMC7495115 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Tsukamoto Hirotake H Kouwaki Takahisa T Oshiumi Hiroyuki H
iScience 20200901 9
Aging-associated changes in the immune system often lead to immune dysfunction; however, the mechanisms that underlie this phenomenon have yet to be fully elucidated. This study found that the microRNA-192 (miR-192) is an aging-associated immune regulatory microRNA whose concentration was significantly increased in aged extracellular vesicles (EVs) due to the hyperinflammatory state of aged mice. Interestingly, EV miR-192 exhibited anti-inflammatory effects on macrophages. In our aged mouse mode ...[more]