Ontology highlight
ABSTRACT:
SUBMITTER: Goulooze SC
PROVIDER: S-EPMC7495284 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Goulooze Sebastiaan C SC Kruithof Annelieke C AC Alikunju Shanavas S Gautam Anirudh A Burggraaf Jacobus J Kamerling Ingrid M C IMC Stevens Jasper J
British journal of clinical pharmacology 20200420 10
We aimed to characterise the population pharmacokinetics of cholesteryl ester transferase protein inhibitor DRL-17822 in healthy males and explore the effect of food and formulation on the oral absorption of DRL-17822 in 4 phase I studies. DRL-17822 was dosed orally (2-1000 mg) in 2 different drug formulations (nanocrystal formulation and amorphous solid dispersion formulation) after either an overnight fast, or a low-fat, continental or high-fat breakfast. A 2-compartment model with 6 transit a ...[more]