Ontology highlight
ABSTRACT:
SUBMITTER: Xiao S
PROVIDER: S-EPMC7496220 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Xiao Sheng S Bod Lloyd L Pochet Nathalie N Kota Savithri Balasubramanian SB Hu Dan D Madi Asaf A Kilpatrick Jessica J Shi Jingwen J Ho Allen A Zhang Huiyuan H Sobel Raymond R Weiner Howard L HL Strom Terry B TB Quintana Francisco J FJ Joller Nicole N Kuchroo Vijay K VK
Cell reports 20200701 2
Tim-1, a phosphatidylserine receptor expressed on B cells, induces interleukin 10 (IL-10) production by sensing apoptotic cells. Here we show that mice with B cell-specific Tim-1 deletion develop tissue inflammation in multiple organs including spontaneous paralysis with inflammation in the central nervous system (CNS). Transcriptomic analysis demonstrates that besides IL-10, Tim-1<sup>+</sup> B cells also differentially express a number of co-inhibitory checkpoint receptors including TIGIT. Mic ...[more]