Deficit of circulating CD19⁺ CD24^hi CD38^hi regulatory B cells in severe aplastic anaemia.

ABSTRACT: Immune aplastic anaemia (AA) is caused by cytotoxic T lymphocytes (CTLs) that destroy haematopoietic stem and progenitor cells. Enhanced type 1 T helper (Th1) responses and reduced regulatory T cells (Tregs) are involved in the immune pathophysiology. CD24^hi CD38^hi regulatory B cells (Bregs) suppress CTLs and Th1 responses, and induce Tregs via interleukin 10 (IL-10). We investigated circulating B-cell subpopulations, including CD24^hi CD38^hi Bregs, as well as total B cells, CD4⁺ T cells, CD8⁺ T cells and natural killer cells in 104 untreated patients with severe and very severe AA, aged ≥18 years. All patients were treated with standard immunosuppressive therapy (IST) plus eltrombopag. CD24^hi CD38^hi Bre

SUBMITTER: Zaimoku Y 

PROVIDER: S-EPMC7496711 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature