Dataset Information

Synthesis and Characterization of the Highly Unstable Metalloid Cluster Ag64 (Pn Bu3 )16 Cl6.

ABSTRACT: The reduction of (n Bu3 P)AgCl with LiBH(s Bu)3 in toluene gives the metalloid silver cluster Ag64 (Pn Bu3 )16 Cl6 (1) as dark red, temperature- and light-sensitive single crystals in high yield. 1 is the largest structurally characterized metalloid silver cluster exhibiting chlorine and phosphine substituents only. The silver atoms in 1 show an overall brick-shape arrangement, where structural resemblance to the close-packed fcc and hcp structures is realized. Within 1 a 58 electron closed shell system is present. The light sensitivity renders 1 as a model compound for the primary seeds of the photo process, whereby this sensitivity, together with the high-yield synthesis show that 1 is a perfect starting compound for further investigations like silver-plating processes.

SUBMITTER: Diecke M

PROVIDER: S-EPMC7496867 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature

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Synthesis and Characterization of the Highly Unstable Metalloid Cluster Ag64 (Pn Bu3 )16 Cl6.

Diecke Maximilian M Schrenk Claudio C Schnepf Andreas A

Angewandte Chemie (International ed. in English) 20200701 34

The reduction of (n Bu3 P)AgCl with LiBH(s Bu)3 in toluene gives the metalloid silver cluster Ag64 (Pn Bu3 )16 Cl6 (1) as dark red, temperature- and light-sensitive single crystals in high yield. 1 is the largest structurally characterized metalloid silver cluster exhibiting chlorine and phosphine substituents only. The silver atoms in 1 show an overall brick-shape arrangement, where structural res ...[more]

PMID: 32453467

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Project description:BackgroundDiacetyl-bis(N4-methylthiosemicarbazone), labeled with 64Cu (64Cu-ATSM) has been suggested as a promising tracer for imaging hypoxia. However, various controversial studies highlighted potential pitfalls that may disable its use as a selective hypoxic marker. They also highlighted that the results may be tumor location dependent. Here, we first analyzed uptake of Cu-ATSM and its less lipophilic counterpart Cu-Cl2 in the tumor over time in an orthotopic glioblastoma model. An in vitro study was also conducted to investigate the hypoxia-dependent copper uptake in tumor cells. We then further performed a comprehensive ex vivo study to compare 64Cu uptake to hypoxic markers, specific cellular reactions, and also transporter expression.MethodsμPET was performed 14 days (18F-FMISO), 15 days (64Cu-ATSM and 64Cu-Cl2), and 16 days (64Cu-ATSM and 64Cu-Cl2) after C6 cell inoculation. Thereafter, the brains were withdrawn for further autoradiography and immunohistochemistry. C6 cells were also grown in hypoxic workstation to analyze cellular uptake of Cu complexes in different oxygen levels.ResultsIn vivo results showed that Cu-ASTM and Cu-Cl2 accumulated in hypoxic areas of the tumors. Cu-ATSM also stained, to a lesser extent, non-hypoxic regions, such as regions of astrogliosis, with high expression of copper transporters and in particular DMT-1 and CTR1, and also characterized by the expression of elevated astrogliosis. In vitro results show that 64Cu-ATSM showed an increase in the uptake only in severe hypoxia at 0.5 and 0.2% of oxygen while for 64Cu-Cl2, the cell retention was significantly increased at 5% and 1% of oxygen with no significant rise at lower oxygen percentages.ConclusionIn the present study, we show that Cu-complexes undoubtedly accumulate in hypoxic areas of the tumors. This uptake may be the reflection of a direct dependency to a redox metabolism and also a reflection of hypoxic-induced overexpression of transporters. We also show that Cu-ATSM also stained non-hypoxic regions such as astrogliosis.

Dataset Information

Synthesis and Characterization of the Highly Unstable Metalloid Cluster Ag64 (Pn Bu3 )16 Cl6.

Publications

Synthesis and Characterization of the Highly Unstable Metalloid Cluster Ag<sub>64</sub> (P<sup>n</sup> Bu<sub>3</sub> )<sub>16</sub> Cl<sub>6</sub>.

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