Ontology highlight
ABSTRACT:
SUBMITTER: De Sousa Linhares A
PROVIDER: S-EPMC7496933 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
European journal of immunology 20200428 8
TIM-3 has been considered as a target in cancer immunotherapy. In T cells, inhibitory as well as activating functions have been ascribed to this molecule. Its role may therefore depend on the state of T cells and on the presence of interaction partners capable to perform functional pairing. Carcinoembryonic antigen-related cell adhesion molecule (CEACAM1) has been proposed to bind TIM-3 and to regulate its function. Using a T cell reporter platform we confirmed CEACAM1-mediated inhibition, but C ...[more]