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Topology-Matching Design of an Influenza-Neutralizing Spiky Nanoparticle-Based Inhibitor with a Dual Mode of Action.

ABSTRACT: In this study, we demonstrate the concept of "topology-matching design" for virus inhibitors. With the current knowledge of influenza?A virus (IAV), we designed a nanoparticle-based inhibitor (nano-inhibitor) that has a matched nanotopology to IAV virions and shows heteromultivalent inhibitory effects on hemagglutinin and neuraminidase. The synthesized nano-inhibitor can neutralize the viral particle extracellularly and block its attachment and entry to the host cells. The virus replication was significantly reduced by 6 orders of magnitude in the presence of the reverse designed nano-inhibitors. Even when used 24?hours after the infection, more than 99.999?% inhibition is still achieved, which indicates such a nano-inhibitor might be a potent antiviral for the treatment of influenza infection.

SUBMITTER: Nie C

PROVIDER: S-EPMC7497169 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature

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Topology-Matching Design of an Influenza-Neutralizing Spiky Nanoparticle-Based Inhibitor with a Dual Mode of Action.

Nie Chuanxiong C Parshad Badri B Bhatia Sumati S Cheng Chong C Stadtmüller Marlena M Oehrl Alexander A Kerkhoff Yannic Y Wolff Thorsten T Haag Rainer R

Angewandte Chemie (International ed. in English) 20200708 36

In this study, we demonstrate the concept of "topology-matching design" for virus inhibitors. With the current knowledge of influenza A virus (IAV), we designed a nanoparticle-based inhibitor (nano-inhibitor) that has a matched nanotopology to IAV virions and shows heteromultivalent inhibitory effects on hemagglutinin and neuraminidase. The synthesized nano-inhibitor can neutralize the viral particle extracellularly and block its attachment and entry to the host cells. The virus replication was ...[more]

PMID: 32421225

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