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Light-Activated Rhenium Complexes with Dual Mode of Action against Bacteria.

ABSTRACT: New antibiotics and innovative approaches to kill drug-resistant bacteria are urgently needed. Metal complexes offer access to alternative modes of action but have only sparingly been investigated in antibacterial drug discovery. We have developed a light-activated rhenium complex with activity against drug-resistant S. aureus and E. coli. The activity profile against mutant strains combined with assessments of cellular uptake and synergy suggest two distinct modes of action.

SUBMITTER: Frei A

PROVIDER: S-EPMC7687258 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

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Light-Activated Rhenium Complexes with Dual Mode of Action against Bacteria.

Frei Angelo A Amado Maite M Cooper Matthew A MA Blaskovich Mark A T MAT

Chemistry (Weinheim an der Bergstrasse, Germany) 20200130 13

New antibiotics and innovative approaches to kill drug-resistant bacteria are urgently needed. Metal complexes offer access to alternative modes of action but have only sparingly been investigated in antibacterial drug discovery. We have developed a light-activated rhenium complex with activity against drug-resistant S. aureus and E. coli. The activity profile against mutant strains combined with assessments of cellular uptake and synergy suggest two distinct modes of action. ...[more]

PMID: 31788867

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