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Microglial remodeling of the extracellular matrix promotes synapse plasticity

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE150714 | GEO | 2020/07/01

REPOSITORIES: GEO

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Microglial Remodeling of the Extracellular Matrix Promotes Synapse Plasticity.

Project description:Synapse remodeling is essential to encode experiences into neuronal circuits. Here, we define a molecular interaction between neurons and microglia that drives experience-dependent synapse remodeling in the hippocampus. We find that the cytokine interleukin-33 (IL-33) is expressed by adult hippocampal neurons in an experience-dependent manner and defines a neuronal subset primed for synaptic plasticity. Loss of neuronal IL-33 or the microglial IL-33 receptor leads to impaired spine plasticity, reduced newborn neuron integration, and diminished precision of remote fear memories. Memory precision and neuronal IL-33 are decreased in aged mice, and IL-33 gain of function mitigates age-related decreases in spine plasticity. We find that neuronal IL-33 instructs microglial engulfment of the extracellular matrix (ECM) and that its loss leads to impaired ECM engulfment and a concomitant accumulation of ECM proteins in contact with synapses. These data define a cellular mechanism through which microglia regulate experience-dependent synapse remodeling and promote memory consolidation.

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Microglial remodeling of the extracellular matrix promotes synapse plasticity [Microglia]

Project description:This study defines a molecular interaction between neurons and microglia that drives experience-dependent synapse remodeling in the hippocampus.

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Microglial remodeling of the extracellular matrix promotes synapse plasticity [Neuronal nuclei]

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Microglial remodeling of the extracellular matrix promotes synapse plasticity

Project description:Microglial remodeling of the extracellular matrix promotes synapse plasticity

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Microglial remodeling of the extracellular matrix promotes synapse plasticity [Microglia]

Project description:Microglial remodeling of the extracellular matrix promotes synapse plasticity [Microglia]

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Microglial remodeling of the extracellular matrix promotes synapse plasticity [Neuronal nuclei]

Project description:Microglial remodeling of the extracellular matrix promotes synapse plasticity [Neuronal nuclei]

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Astrocyte-derived Interleukin-33 promotes microglial synapse engulfment and neural circuit development

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