Ontology highlight
ABSTRACT:
SUBMITTER: Orefice NS
PROVIDER: S-EPMC7498263 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Orefice Nicola S NS Guillemot-Legris Owein O Capasso Rosanna R Bottemanne Pauline P Hantraye Philippe P Caraglia Michele M Orefice Giuseppe G Alhouayek Mireille M Muccioli Giulio G GG
eLife 20200917
Cortical lesions represent a hallmark of multiple sclerosis and are proposed as a predictor of disease severity. microRNAs are suggested to be important players in the disease pathogenesis and the experimental autoimmune encephalomyelitis animal model. We implemented a mouse model recapitulating more closely the human pathology as it is characterized by both an autoimmune heterogeneity and the presence of cortical lesions, two parameters missing in experimental autoimmune encephalomyelitis. In o ...[more]