Ontology highlight
ABSTRACT:
SUBMITTER: Aikin TJ
PROVIDER: S-EPMC7498266 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Aikin Timothy J TJ Peterson Amy F AF Pokrass Michael J MJ Clark Helen R HR Regot Sergi S
eLife 20200917
A large fraction of human cancers contain genetic alterations within the Mitogen Activated Protein Kinase (MAPK) signaling network that promote unpredictable phenotypes. Previous studies have shown that the temporal patterns of MAPK activity (i.e. signaling dynamics) differentially regulate cell behavior. However, the role of signaling dynamics in mediating the effects of cancer driving mutations has not been systematically explored. Here, we show that oncogene expression leads to either pulsati ...[more]