Ontology highlight
ABSTRACT:
SUBMITTER: Wu D
PROVIDER: S-EPMC7498369 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Wu Dehai D Wang Yan Y Yang Guangchao G Zhang Shugeng S Liu Yao Y Zhou Shuo S Guo Hongrui H Liang Shuhang S Cui Yifeng Y Zhang Bo B Ma Kun K Zhang Congyi C Liu Yufeng Y Sun Linmao L Wang Jiabei J Liu Lianxin L
Oncogene 20200818 38
Hepatocellular carcinoma (HCC) is the fifth leading cause of cancer-related mortality in the United States. Exploring the mechanism of HCC and identifying ideal targets is critical. In the present study, we demonstrated metabolism dysfunction might be a key diver for the development of HCC. The mitochondrial amidoxime reducing component 2 (MARC2) as a newly discovered molybdenum enzyme was downregulated in human HCC tissues and HCC cells. Downregulated MARC2 was significantly associated with cli ...[more]