Asperuloside Improves Obesity and Type 2 Diabetes through Modulation of Gut Microbiota and Metabolic Signaling.
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ABSTRACT:
SUBMITTER: Nakamura A
PROVIDER: S-EPMC7498753 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
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Asperuloside Improves Obesity and Type 2 Diabetes through Modulation of Gut Microbiota and Metabolic Signaling.
Nakamura Anna A Yokoyama Yoko Y Tanaka Kazuki K Benegiamo Giorgia G Hirayama Akiyoshi A Zhu Qi Q Kitamura Naho N Sugizaki Taichi T Morimoto Kohkichi K Itoh Hiroshi H Fukuda Shinji S Auwerx Johan J Tsubota Kazuo K Watanabe Mitsuhiro M
iScience 20200902 9
Asperuloside (ASP) is an iridoid glycoside that is extracted from <i>Eucommia</i> leaves. <i>Eucommia</i> is used in traditional Chinese medicine and has a long history of benefits on health and longevity. Here, we investigated the impact of ASP on obesity-related metabolic disorders and show that ASP reduces body weight gain, glucose intolerance, and insulin resistance effectively in mice fed with a high-fat diet (HFD). Intestinal dysbiosis is closely linked with metabolic disorders. Our data i ...[more]
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