Unknown

Dataset Information

0

Asperuloside Improves Obesity and Type 2 Diabetes through Modulation of Gut Microbiota and Metabolic Signaling.


ABSTRACT: Asperuloside (ASP) is an iridoid glycoside that is extracted from Eucommia leaves. Eucommia is used in traditional Chinese medicine and has a long history of benefits on health and longevity. Here, we investigated the impact of ASP on obesity-related metabolic disorders and show that ASP reduces body weight gain, glucose intolerance, and insulin resistance effectively in mice fed with a high-fat diet (HFD). Intestinal dysbiosis is closely linked with metabolic disorders. Our data indicate that ASP achieves these benefits on metabolic homeostasis by reversing HFD-induced gut dysbiosis and by changing gut-derived secondary metabolites and metabolic signaling. Our results indicate that ASP may be used to regulate gut microbiota for the treatment of obesity and type 2 diabetes.

SUBMITTER: Nakamura A 

PROVIDER: S-EPMC7498753 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

altmetric image

Publications


Asperuloside (ASP) is an iridoid glycoside that is extracted from <i>Eucommia</i> leaves. <i>Eucommia</i> is used in traditional Chinese medicine and has a long history of benefits on health and longevity. Here, we investigated the impact of ASP on obesity-related metabolic disorders and show that ASP reduces body weight gain, glucose intolerance, and insulin resistance effectively in mice fed with a high-fat diet (HFD). Intestinal dysbiosis is closely linked with metabolic disorders. Our data i  ...[more]

Similar Datasets

| S-EPMC8724542 | biostudies-literature
| S-EPMC9045376 | biostudies-literature
| S-EPMC7019423 | biostudies-literature
| S-EPMC10800606 | biostudies-literature
| S-EPMC9388534 | biostudies-literature
| S-EPMC7468698 | biostudies-literature
| S-EPMC5968592 | biostudies-literature
| S-EPMC8716487 | biostudies-literature
| S-EPMC6603011 | biostudies-other
| S-EPMC4808856 | biostudies-literature