Ontology highlight
ABSTRACT:
SUBMITTER: Fornari C
PROVIDER: S-EPMC7499189 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Fornari Chiara C Pin Carmen C Yates James W T JWT Mettetal Jerome T JT Collins Teresa A TA
CPT: pharmacometrics & systems pharmacology 20200708 9
Stability analysis, often overlooked in pharmacometrics, is essential to explore dynamical systems. The model developed by Friberg et al.<sup>1</sup> to describe drug-induced hematotoxicity is widely used to support decisions across drug development, and parameter values are often identified from observed blood counts. We use stability analysis to study the parametric dependence of stable and unstable solutions of several Friberg-type models and highlight the risks associated with system instabi ...[more]