Ontology highlight
ABSTRACT:
SUBMITTER: Shapiro MR
PROVIDER: S-EPMC7500101 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Shapiro Melanie R MR Yeh Wen-I WI Longfield Joshua R JR Gallagher John J Infante Caridad M CM Wellford Sarah S Posgai Amanda L AL Atkinson Mark A MA Campbell-Thompson Martha M Lieberman Scott M SM Serreze David V DV Geurts Aron M AM Chen Yi-Guang YG Brusko Todd M TM
Frontiers in immunology 20200904
The costimulatory molecule CD226 is highly expressed on effector/memory T cells and natural killer cells. Costimulatory signals received by T cells can impact both central and peripheral tolerance mechanisms. Genetic polymorphisms in <i>CD226</i> have been associated with susceptibility to type 1 diabetes and other autoimmune diseases. We hypothesized that genetic deletion of <i>Cd226</i> in the non-obese diabetic (NOD) mouse would impact type 1 diabetes incidence by altering T cell activation. ...[more]