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A nutrient-wide association study for risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition and the Netherlands Cohort Study.

ABSTRACT: PURPOSE:The evidence from the literature regarding the association of dietary factors and risk of prostate cancer is inconclusive. METHODS:A nutrient-wide association study was conducted to systematically and comprehensively evaluate the associations between 92 foods or nutrients and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). Cox proportional hazard regression models adjusted for total energy intake, smoking status, body mass index, physical activity, diabetes and education were used to estimate hazard ratios and 95% confidence intervals for standardized dietary intakes. As in genome-wide association studies, correction for multiple comparisons was applied using the false discovery rate (FDR?

SUBMITTER: Papadimitriou N 

PROVIDER: S-EPMC7501135 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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A nutrient-wide association study for risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition and the Netherlands Cohort Study.

Papadimitriou Nikos N   Muller David D   van den Brandt Piet A PA   Geybels Milan M   Patel Chirag J CJ   Gunter Marc J MJ   Lopez David S DS   Key Timothy J TJ   Perez-Cornago Aurora A   Ferrari Pietro P   Vineis Paolo P   Weiderpass Elisabete E   Boeing Heiner H   Agudo Antonio A   Sánchez María-José MJ   Overvad Kim K   Kühn Tilman T   Fortner Renee T RT   Palli Domenico D   Drake Isabel I   Bjartell Anders A   Santiuste Carmen C   Bueno-de-Mesquita Bas H BH   Krogh Vittorio V   Tjønneland Anne A   Lauritzen Dorthe Furstrand DF   Gurrea Aurelio Barricarte AB   Quirós José Ramón JR   Stattin Pär P   Trichopoulou Antonia A   Martimianaki Georgia G   Karakatsani Anna A   Thysell Elin E   Johansson Ingegerd I   Ricceri Fulvio F   Tumino Rosario R   Larrañaga Nerea N   Khaw Kay Tee KT   Riboli Elio E   Tzoulaki Ioanna I   Tsilidis Konstantinos K KK  

European journal of nutrition 20191108 7

<h4>Purpose</h4>The evidence from the literature regarding the association of dietary factors and risk of prostate cancer is inconclusive.<h4>Methods</h4>A nutrient-wide association study was conducted to systematically and comprehensively evaluate the associations between 92 foods or nutrients and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). Cox proportional hazard regression models adjusted for total energy intake, smoking status, body mas  ...[more]

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