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Main nutrient patterns and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition study.


ABSTRACT: Much of the current literature on diet-colorectal cancer (CRC) associations focused on studies of single foods/nutrients, whereas less is known about nutrient patterns. We investigated the association between major nutrient patterns and CRC risk in participants of the European Prospective Investigation into Cancer and Nutrition (EPIC) study.Among 477?312 participants, intakes of 23 nutrients were estimated from validated dietary questionnaires. Using results from a previous principal component (PC) analysis, four major nutrient patterns were identified. Hazard ratios (HRs) and 95% confidence intervals (CIs) were computed for the association of each of the four patterns and CRC incidence using multivariate Cox proportional hazards models with adjustment for established CRC risk factors.During an average of 11 years of follow-up, 4517 incident cases of CRC were documented. A nutrient pattern characterised by high intakes of vitamins and minerals was inversely associated with CRC (HR per 1 s.d.=0.94, 95% CI: 0.92-0.98) as was a pattern characterised by total protein, riboflavin, phosphorus and calcium (HR (1 s.d.)=0.96, 95% CI: 0.93-0.99). The remaining two patterns were not significantly associated with CRC risk.Analysing nutrient patterns may improve our understanding of how groups of nutrients relate to CRC.

SUBMITTER: Moskal A 

PROVIDER: S-EPMC5129834 | biostudies-other | 2016 Nov

REPOSITORIES: biostudies-other

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Main nutrient patterns and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition study.

Moskal Aurélie A   Freisling Heinz H   Byrnes Graham G   Assi Nada N   Fahey Michael T MT   Jenab Mazda M   Ferrari Pietro P   Tjønneland Anne A   Petersen Kristina En KE   Dahm Christina C CC   Hansen Camilla Plambeck CP   Affret Aurélie A   Boutron-Ruault Marie-Christine MC   Cadeau Claire C   Kühn Tilman T   Katzke Verena V   Iqbal Khalid K   Boeing Heiner H   Trichopoulou Antonia A   Bamia Christina C   Naska Androniki A   Masala Giovanna G   de Magistris Maria Santucci MS   Sieri Sabina S   Tumino Rosario R   Sacerdote Carlotta C   Peeters Petra H PH   Bueno-de-Mesquita Bas H BH   Engeset Dagrun D   Licaj Idlir I   Skeie Guri G   Ardanaz Eva E   Buckland Genevieve G   Castaño José M Huerta JM   Quirós José R JR   Amiano Pilar P   Molina-Portillo Elena E   Winkvist Anna A   Myte Robin R   Ericson Ulrika U   Sonestedt Emily E   Perez-Cornago Aurora A   Wareham Nick N   Khaw Kay-Tee KT   Huybrechts Inge I   Tsilidis Konstantinos K KK   Ward Heather H   Gunter Marc J MJ   Slimani Nadia N  

British journal of cancer 20161020 11


<h4>Background</h4>Much of the current literature on diet-colorectal cancer (CRC) associations focused on studies of single foods/nutrients, whereas less is known about nutrient patterns. We investigated the association between major nutrient patterns and CRC risk in participants of the European Prospective Investigation into Cancer and Nutrition (EPIC) study.<h4>Methods</h4>Among 477 312 participants, intakes of 23 nutrients were estimated from validated dietary questionnaires. Using results fr  ...[more]

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