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Effect of punicalagin and human chorionic gonadotropin on body weight and reproductive traits in maiden rabbit does.

ABSTRACT: Highlights • Punicalagin as a potential antioxidant against free radicals in combination with human chorionic gonadotropin as an auxiliary factor in increasing progesterone levels from accessory corpus luteum enhance reproductive and pregnancy health in young does.• Free radicals produced from reproductive processes may disturb oocyte and embryo growth.• Injection of punicalagin (PL) alone or in combination with human chorionic gonadotropin (HCG) had significant impacts on maternal body weight (MBW), conception rate (CR), gestation length (GL), kindling rate (KR), total litter size (TLS), live litter size (LLS), kit weight (KW) and progesterone (P4) concentrations during 1st/2nd gestation periods. Little is known about the effect of punicalagin extracted from pomegranate or in combination with human chorionic gonadotropin on enhancing the productive and reproductive performance in rabbits that gestate for the first time. The impact of punicalagin alone or in combination with human chorionic gonadotropin on maiden doe body weight, progesterone concentrations, conception rate, gestation rate, litter size, and kit weight was investigated in this study. A completely randomized and balanced experimental design was used to allocate 21 naturally mated maiden does at 6 months of age into the following three treatment groups of 7 does each: Control - intramuscular injection with sterilized water only; Treatment 1 - pre-mating intramuscular injection with punicalagin (100 µg/doe) twice a week and once 3 days post-mating; and Treatment 2 - pre-mating intramuscular injection with punicalagin twice a week and human chorionic gonadotropin (25 IU/doe) once 3 days post-mating. Progesterone was assayed from blood samples taken from the ear marginal vein at mating, post-mating, gestation, and post-kindling phases when all does were weighed. Results indicated significantly positive impacts of punicalagin alone or in combination with human chorionic gonadotropin on all doe reproductive traits, birth, and weaning weights of kits. The study clearly demonstrated an improvement in doe fertility, reproductive performance, and kit survival to weaning. In conclusion, PL and PL+HCG improved maternal body weights and their offspring as well as pregnancy outcomes of young rabbits particularly in the 2nd pregnancy, hence findings of this study could be recommended for improving reproductive health and fertility in maiden rabbit does.

SUBMITTER: Salem A

PROVIDER: S-EPMC7501459 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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Effect of punicalagin and human chorionic gonadotropin on body weight and reproductive traits in maiden rabbit does.

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