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Impact of Treatment with Renin-Angiotensin System Inhibitors on Clinical Outcomes in Hypertensive Patients Hospitalized with COVID-19.


ABSTRACT:

Introduction

Concerns have been raised about the possible harmfulness of angiotensin-converter enzyme inhibitors (ACEi) and aldosterone receptor blockers (ARB) in patients with COVID-19. However, few data from a European population have been published, especially from hypertensive patients.

Aim

To study the association between ACEi or ARB treatments and major adverse outcomes during hospitalisation in COVID-19 patients.

Methods

We studied 545 consecutive hypertensive patients admitted to our institution due to COVID-19 with respiratory involvement. We analysed the incidence of combined event (death or mechanical ventilatory support) during hospitalisation, as well as the time to independent events.

Results

188 (34.5%) patients presented the combined endpoint. 1

SUBMITTER: Negreira-Caamano M 

PROVIDER: S-EPMC7501502 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

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