Epigenetic Regulation in Mesenchymal Stem Cell Aging and Differentiation and Osteoporosis.
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ABSTRACT:
SUBMITTER: Wang R
PROVIDER: S-EPMC7501554 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
Epigenetic Regulation in Mesenchymal Stem Cell Aging and Differentiation and Osteoporosis.
Wang Ruoxi R Wang Yu Y Zhu Lisha L Liu Yan Y Li Weiran W
Stem cells international 20200910
Mesenchymal stem cells (MSCs) are a reliable source for cell-based regenerative medicine owing to their multipotency and biological functions. However, aging-induced systemic homeostasis disorders <i>in vivo</i> and cell culture passaging <i>in vitro</i> induce a functional decline of MSCs, switching MSCs to a senescent status with impaired self-renewal capacity and biased differentiation tendency. MSC functional decline accounts for the pathogenesis of many diseases and, more importantly, limit ...[more]
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