Ontology highlight
ABSTRACT:
SUBMITTER: Pinkosky SL
PROVIDER: S-EPMC7502547 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Pinkosky Stephen L SL Scott John W JW Desjardins Eric M EM Smith Brennan K BK Day Emily A EA Ford Rebecca J RJ Langendorf Christopher G CG Ling Naomi X Y NXY Nero Tracy L TL Loh Kim K Galic Sandra S Hoque Ashfaqul A Smiles William J WJ Ngoei Kevin R W KRW Parker Michael W MW Yan Yan Y Melcher Karsten K Kemp Bruce E BE Oakhill Jonathan S JS Steinberg Gregory R GR
Nature metabolism 20200727 9
Long-chain fatty acids (LCFAs) play important roles in cellular energy metabolism, acting as both an important energy source and signalling molecules<sup>1</sup>. LCFA-CoA esters promote their own oxidation by acting as allosteric inhibitors of acetyl-CoA carboxylase, which reduces the production of malonyl-CoA and relieves inhibition of carnitine palmitoyl-transferase 1, thereby promoting LCFA-CoA transport into the mitochondria for β-oxidation<sup>2-6</sup>. Here we report a new level of regul ...[more]