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Multivalent weak interactions enhance selectivity of interparticle binding.

ABSTRACT: Targeted drug delivery critically depends on the binding selectivity of cargo-transporting colloidal particles. Extensive theoretical work has shown that two factors are necessary to achieve high selectivity for a threshold receptor density: multivalency and weak interactions. Here, we study a model system of DNA-coated particles with multivalent and weak interactions that mimics ligand-receptor interactions between particles and cells. Using an optomagnetic cluster experiment, particle aggregation rates are measured as a function of ligand and receptor densities. The measured aggregation rates show that the binding becomes more selective for shorter DNA ligand-receptor pairs, proving that multivalent weak interactions lead to enhanced selectivity in interparticle binding. Simulations confirm the experimental findings and show the role of ligand-receptor dissociation in the selectivity of the weak multivalent binding.

SUBMITTER: Scheepers MRW

PROVIDER: S-EPMC7502730 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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Multivalent weak interactions enhance selectivity of interparticle binding.

Scheepers M R W MRW van IJzendoorn L J LJ Prins M W J MWJ

Proceedings of the National Academy of Sciences of the United States of America 20200828 37

Targeted drug delivery critically depends on the binding selectivity of cargo-transporting colloidal particles. Extensive theoretical work has shown that two factors are necessary to achieve high selectivity for a threshold receptor density: multivalency and weak interactions. Here, we study a model system of DNA-coated particles with multivalent and weak interactions that mimics ligand-receptor interactions between particles and cells. Using an optomagnetic cluster experiment, particle aggregat ...[more]

PMID: 32859760

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