Ontology highlight
ABSTRACT:
SUBMITTER: Liu WH
PROVIDER: S-EPMC7568541 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Liu Wallace H WH Zheng Jie J Feldman Jessica L JL Klein Mark A MA Kuznetsov Vyacheslav I VI Peterson Craig L CL Griffin Patrick R PR Denu John M JM
Nature communications 20201016 1
The protein deacetylase SIRT6 maintains cellular homeostasis through multiple pathways that include the deacetylation of histone H3 and repression of transcription. Prior work suggests that SIRT6 is associated with chromatin and can substantially reduce global levels of H3 acetylation, but how SIRT6 is able to accomplish this feat is unknown. Here, we describe an exquisitely tight interaction between SIRT6 and nucleosome core particles, in which a 2:1 enzyme:nucleosome complex assembles via asym ...[more]