Adipose Tissue Fibrosis: Mechanisms, Models, and Importance.
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ABSTRACT:
SUBMITTER: DeBari MK
PROVIDER: S-EPMC7503256 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Publications
Adipose Tissue Fibrosis: Mechanisms, Models, and Importance.
DeBari Megan K MK Abbott Rosalyn D RD
International journal of molecular sciences 20200821 17
Increases in adipocyte volume and tissue mass due to obesity can result in inflammation, further dysregulation in adipose tissue function, and eventually adipose tissue fibrosis. Like other fibrotic diseases, adipose tissue fibrosis is the accumulation and increased production of extracellular matrix (ECM) proteins. Adipose tissue fibrosis has been linked to decreased insulin sensitivity, poor bariatric surgery outcomes, and difficulty in weight loss. With the rising rates of obesity, it is impo ...[more]
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