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Concise Total Synthesis and Antifungal Activities of Fusaric Acid, a Natural Product.

ABSTRACT: The total synthesis of a natural product alkaloid fusaric acid (FA), which exhibits herbicide, fungicide, insecticide and even diverse notable pharmacological activities, was accomplished in four steps using commercially available materials. The synthesis, based on a unified and flexible strategy using 6-bromonicotinaldehyde as a common intermediate, is concise, convergent, practical and can be carried out on a two-gram scale. This approach could be readily applicable to the synthesis of its analogues. In addition, FA had a wide range of inhibitory activities against 14 plant pathogenic fungi in this study, which demonstrated that as a leading compound, and it has great potential to be further developed as an agricultural fungicide.

SUBMITTER: Huang BB

PROVIDER: S-EPMC7503603 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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Concise Total Synthesis and Antifungal Activities of Fusaric Acid, a Natural Product.

Huang Bin Bin BB Liu Ya Yi YY Zhu Peng Fei PF Jiang Yi Cheng YC Ouyang Ming-An MA

Molecules (Basel, Switzerland) 20200825 17

The total synthesis of a natural product alkaloid fusaric acid (FA), which exhibits herbicide, fungicide, insecticide and even diverse notable pharmacological activities, was accomplished in four steps using commercially available materials. The synthesis, based on a unified and flexible strategy using 6-bromonicotinaldehyde as a common intermediate, is concise, convergent, practical and can be carried out on a two-gram scale. This approach could be readily applicable to the synthesis of its ana ...[more]

PMID: 32854261

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