An Atomic-Level Perspective of HMG-CoA-Reductase: The Target Enzyme to Treat Hypercholesterolemia.
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ABSTRACT:
SUBMITTER: Gesto DS
PROVIDER: S-EPMC7503714 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Publications
An Atomic-Level Perspective of HMG-CoA-Reductase: The Target Enzyme to Treat Hypercholesterolemia.
Gesto Diana S DS Pereira Carlos M S CMS Cerqueira Nuno M F S NMFS Sousa Sérgio F SF
Molecules (Basel, Switzerland) 20200826 17
This review provides an updated atomic-level perspective regarding the enzyme 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoAR), linking the more recent data on this enzyme with a structure/function interpretation. This enzyme catalyzes one of the most important steps in cholesterol biosynthesis and is regarded as one of the most important drug targets in the treatment of hypercholesterolemia. Taking this into consideration, we review in the present article several aspects of this enzym ...[more]
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