Ontology highlight
ABSTRACT:
SUBMITTER: Zhang S
PROVIDER: S-EPMC7505520 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Zhang Shizhen S Shen Yanwen Y Li Hua H Bi Chao C Sun Yilun Y Xiong Xiufang X Wei Wenyi W Sun Yi Y
Cell reports 20200901 10
Anaphase-promoting complex/cyclosome (APC/C) is a well-characterized E3 ligase that couples with UBE2C and UBE2S E2s for substrate ubiquitylation by the K11 linkage. Our recent data show that SAG/RBX2/ROC2, a RING component of Cullin-RING E3 ligase, also complexes with these E2s for K11-linked substrate polyubiquitylation. Whether these two E3s cross-talk with each other was previously unknown. Here, we report that SAG competes with APC2 for UBE2C/UBE2S binding to act as a potential endogenous i ...[more]