Ontology highlight
ABSTRACT:
SUBMITTER: Li Y
PROVIDER: S-EPMC7505657 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Li Yulan Y Li Lixuan L Wu Jintao J Zhu Zhenggang Z Feng Xiang X Qin Liming L Zhu Yuwei Y Sun Li L Liu Yijun Y Qiu Zilong Z Duan Shumin S Yu Yan-Qin YQ
eLife 20200901
Astrocytes respond to and regulate neuronal activity, yet their role in mammalian behavior remains incompletely understood. Especially unclear is whether, and if so how, astrocyte activity regulates contextual fear memory, the dysregulation of which leads to pathological fear-related disorders. We generated <i>GFAP-ChR2-EYFP</i> rats to allow the specific activation of astrocytes in vivo by optogenetics. We found that after memory acquisition within a temporal window, astrocyte activation disrup ...[more]