Feeding desensitizes A1 adenosine receptors in adipose through FOXO1-mediated transcriptional regulation.

ABSTRACT:

Objective

Adipose tissue is a critical regulator of energy balance that must rapidly shift its metabolism between fasting and feeding to maintain homeostasis. Adenosine has been characterized as an important regulator of adipocyte metabolism primarily through its actions on A₁ adenosine receptors (A1R). We sought to understand the role A1R plays specifically in adipocytes during fasting and feeding to regulate glucose and lipid metabolism.

Methods

We used Adora1 floxed mice with an inducible, adiponectin-Cre to generate FAdora1^-/- mice, where F designates a fat-specific deletion of A1R. We used these FAdora1^-/- mice along with specific agonists and antagonists of A1R to investigate changes in adenosine signaling within adipocytes between the

SUBMITTER: Granade ME 

PROVIDER: S-EPMC9304768 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature