Ontology highlight
ABSTRACT:
SUBMITTER: Fan S
PROVIDER: S-EPMC7505887 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Fan S S Liao Y Y Qiu W W Li L L Li D D Cao X X Ai B B
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 20200504 11
<h4>Purpose</h4>Estrogen plays a critical role in the invasiveness and metastasis of non-small cell lung cancer (NSCLC) through estrogen receptor β (ERβ). However, the antimetastatic effect of the ERβ antagonist fulvestrant was still limited in NSCLC patients. Recently, Toll-like receptor 4 (TLR4) signaling was implicated in NSCLC metastasis. Our present study aimed to evaluate the synergistic antimetastatic effect of a combination of fulvestrant and the TLR4-specific inhibitor CLI-095 (TAK-242) ...[more]