Genome-wide resolution peripheral blood methylome profiling reveals signatures for cholestatic liver disease.
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ABSTRACT:
SUBMITTER: Moore RM
PROVIDER: S-EPMC7506472 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
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Genome-wide resolution peripheral blood methylome profiling reveals signatures for cholestatic liver disease.
Moore Raymond M RM Sun Zhifu Z Juran Brian D BD Lazaridis Konstantinos N KN
Epigenomics 20200801 16
<b>Aim:</b> To profile DNA methylation changes of primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC). <b>Materials & methods:</b> Patients with: PBC, PSC with inflammatory bowel disease (IBD), PSC without IBD, and age-, sex-matched controls were profiled for methylomes of peripheral blood by reduced representation bisulfite sequencing. Differentially methylated CpG (DMC) and differentially methylated region (DMR) were detected and compared. <b>Results:</b> We identified c ...[more]
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