Ontology highlight
ABSTRACT:
SUBMITTER: Dogra P
PROVIDER: S-EPMC7507140 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Dogra Prashant P Butner Joseph D JD Nizzero Sara S Ruiz Ramírez Javier J Noureddine Achraf A Peláez María J MJ Elganainy Dalia D Yang Zhen Z Le Anh-Dung AD Goel Shreya S Leong Hon S HS Koay Eugene J EJ Brinker C Jeffrey CJ Cristini Vittorio V Wang Zhihui Z
Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology 20200421 5
While plasma concentration kinetics has traditionally been the predictor of drug pharmacological effects, it can occasionally fail to represent kinetics at the site of action, particularly for solid tumors. This is especially true in the case of delivery of therapeutic macromolecules (drug-loaded nanomaterials or monoclonal antibodies), which can experience challenges to effective delivery due to particle size-dependent diffusion barriers at the target site. As a result, disparity between therap ...[more]