Ontology highlight
ABSTRACT:
SUBMITTER: Edwards DS
PROVIDER: S-EPMC7507985 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Cell reports 20200901 12
Effective spatio-temporal control of transcription and replication during S-phase is paramount to maintaining genomic integrity and cell survival. Dysregulation of these systems can lead to conflicts between the transcription and replication machinery, causing DNA damage and cell death. BRD4 allows efficient transcriptional elongation by stimulating phosphorylation of RNA polymerase II (RNAPII). We report that bromodomain and extra-terminal domain (BET) protein loss of function (LOF) causes RNAP ...[more]