Ontology highlight
ABSTRACT:
SUBMITTER: Dagher R
PROVIDER: S-EPMC7508874 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Dagher Rania R Copenhaver Alan M AM Besnard Valerie V Berlin Aaron A Hamidi Fatima F Maret Marielle M Wang Jingya J Qu Xiaotao X Shrestha Yashaswi Y Wu Jincheng J Gautier Gregory G Raja Rajiv R Aubier Michel M Kolbeck Roland R Humbles Alison A AA Pretolani Marina M
Nature communications 20200922 1
Evidence points to an indispensable function of macrophages in tissue regeneration, yet the underlying molecular mechanisms remain elusive. Here we demonstrate a protective function for the IL-33-ST2 axis in bronchial epithelial repair, and implicate ST2 in myeloid cell differentiation. ST2 deficiency in mice leads to reduced lung myeloid cell infiltration, abnormal alternatively activated macrophage (AAM) function, and impaired epithelial repair post naphthalene-induced injury. Reconstitution o ...[more]