Ontology highlight
ABSTRACT:
SUBMITTER: Sheedlo MJ
PROVIDER: S-EPMC7511236 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Sheedlo Michael J MJ Chung Jeong Min JM Sawhney Neha N Durie Clarissa L CL Cover Timothy L TL Ohi Melanie D MD Lacy D Borden DB
eLife 20200902
The pathogenesis of <i>Helicobacter pylori</i>-associated gastric cancer is dependent on delivery of CagA into host cells through a type IV secretion system (T4SS). The <i>H. pylori</i> Cag T4SS includes a large membrane-spanning core complex containing five proteins, organized into an outer membrane cap (OMC), a periplasmic ring (PR) and a stalk. Here, we report cryo-EM reconstructions of a core complex lacking Cag3 and an improved map of the wild-type complex. We define the structures of two u ...[more]