Repurposing anti-inflammasome NRTIs for improving insulin sensitivity and reducing type 2 diabetes development.
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ABSTRACT:
SUBMITTER: Ambati J
PROVIDER: S-EPMC7511405 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
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Repurposing anti-inflammasome NRTIs for improving insulin sensitivity and reducing type 2 diabetes development.
Ambati Jayakrishna J Magagnoli Joseph J Leung Hannah H Wang Shao-Bin SB Andrews Chris A CA Fu Dongxu D Pandey Akshat A Sahu Srabani S Narendran Siddharth S Hirahara Shuichiro S Fukuda Shinichi S Sun Jian J Pandya Lekha L Ambati Meenakshi M Pereira Felipe F Varshney Akhil A Cummings Tammy T Hardin James W JW Edun Babatunde B Bennett Charles L CL Ambati Kameshwari K Fowler Benjamin J BJ Kerur Nagaraj N Röver Christian C Leitinger Norbert N Werner Brian C BC Stein Joshua D JD Sutton S Scott SS Gelfand Bradley D BD
Nature communications 20200923 1
Innate immune signaling through the NLRP3 inflammasome is activated by multiple diabetes-related stressors, but whether targeting the inflammasome is beneficial for diabetes is still unclear. Nucleoside reverse-transcriptase inhibitors (NRTI), drugs approved to treat HIV-1 and hepatitis B infections, also block inflammasome activation. Here, we show, by analyzing five health insurance databases, that the adjusted risk of incident diabetes is 33% lower in patients with NRTI exposure among 128,861 ...[more]
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