Rapid senescence-like response after acute injury.
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ABSTRACT:
SUBMITTER: Chu X
PROVIDER: S-EPMC7511876 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Publications
Rapid senescence-like response after acute injury.
Chu Xiaogang X Wen Jin J Raju Raghavan Pillai RP
Aging cell 20200802 9
Cellular senescence is a state of irreversible growth arrest. Short-term programmed senescence such as in embryonic development and slowly progressing senescence as in aging are both well described. However, acute senescence in living organisms is not well understood. We hypothesized that hemorrhagic shock injury (HI) caused by whole body hypoxia and nutrient deprivation, resulting in organ dysfunction due to severe blood loss, could lead to acute senescence in vivo. Our experiments, for the fir ...[more]
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