Ontology highlight
ABSTRACT:
SUBMITTER: Faust HJ
PROVIDER: S-EPMC7524483 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Faust Heather J HJ Zhang Hong H Han Jin J Wolf Matthew T MT Jeon Ok Hee OH Sadtler Kaitlyn K Peña Alexis N AN Chung Liam L Maestas David R DR Tam Ada J AJ Pardoll Drew M DM Campisi Judith J Housseau Franck F Zhou Daohong D Bingham Clifton O CO Elisseeff Jennifer H JH
The Journal of clinical investigation 20201001 10
Senescent cells (SnCs) are implicated in the pathogenesis of age-related diseases including osteoarthritis (OA), in part via expression of a senescence-associated secretory phenotype (SASP) that includes immunologically relevant factors and cytokines. In a model of posttraumatic OA (PTOA), anterior cruciate ligament transection (ACLT) induced a type 17 immune response in the articular compartment and draining inguinal lymph nodes (LNs) that paralleled expression of the senescence marker p16INK4a ...[more]