The NRF2-related interactome and regulome contain multifunctional proteins and fine-tuned autoregulatory loops.
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ABSTRACT:
SUBMITTER: Papp D
PROVIDER: S-EPMC7511993 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Publications
The NRF2-related interactome and regulome contain multifunctional proteins and fine-tuned autoregulatory loops.
Papp Diána D Lenti Katalin K Módos Dezső D Fazekas Dávid D Dúl Zoltán Z Türei Dénes D Földvári-Nagy László L Nussinov Ruth R Csermely Péter P Korcsmáros Tamás T
FEBS letters 20120526 13
NRF2 is a well-known, master transcription factor (TF) of oxidative and xenobiotic stress responses. Recent studies uncovered an even wider regulatory role of NRF2 influencing carcinogenesis, inflammation and neurodegeneration. Prompted by these advances here we present a systems-level resource for NRF2 interactome and regulome that includes 289 protein-protein, 7469 TF-DNA and 85 miRNA interactions. As systems-level examples of NRF2-related signaling we identified regulatory loops of NRF2 inter ...[more]
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