Ontology highlight
ABSTRACT:
SUBMITTER: Cen L
PROVIDER: S-EPMC7512074 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Cen Lusha L Xing Fengling F Xu Liying L Cao Yi Y
Journal of diabetes research 20200915
Nuclear factor of activated T cells 5 (NFAT5), a Rel/nuclear factor- (NF-) <i>κ</i>B family member, is the only known gene regulator of the mammalian adaptive response to osmotic stress. Exposure to elevated glucose increases the expression and nuclear translocation of NFAT5, as well as NFAT5-driven transcriptional activity in vivo and in vitro. Increased expression of NFAT5 is closely correlated with the progression of diabetes in patients. The distinct structure of NFAT5 governs its physiologi ...[more]