Ontology highlight
ABSTRACT:
SUBMITTER: Paschou SA
PROVIDER: S-EPMC5776665 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Paschou Stavroula A SA Papadopoulou-Marketou Nektaria N Chrousos George P GP Kanaka-Gantenbein Christina C
Endocrine connections 20171130 1
Type 1 diabetes mellitus (T1DM) results from the autoimmune destruction of β cells of the endocrine pancreas. Pathogenesis of T1DM is different from that of type 2 diabetes mellitus, where both insulin resistance and reduced secretion of insulin by the β cells play a synergistic role. We will present genetic, environmental and immunologic factors that destroy β cells of the endocrine pancreas and lead to insulin deficiency. The process of autoimmune destruction takes place in genetically suscept ...[more]