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A comparison of a ketogenic diet with a LowGI/nutrigenetic diet over 6?months for weight loss and 18-month follow-up.

ABSTRACT: Background:Obesity and its related metabolic disturbances represent a huge health burden on society. Many different weight loss interventions have been trialled with mixed efficacy, as demonstrated by the large number of individuals who regain weight upon completion of such interventions. There is evidence that the provision of genetic information may enhance long-term weight loss, either by increasing dietary adherence or through underlying biological mechanisms. Methods:The investigators followed 114 overweight and obese subjects from a weight loss clinic in a 2-stage process. 1) A 24-week dietary intervention. The subjects self-selected whether to follow a standardized ketogenic diet (n?=?53), or a personalised low-glycemic index (GI) nutrigenetic diet utilising information from 28 single nucleotide polymorphisms (n?=?61). 2) After the 24-week diet period, the subjects were monitored for an additional 18?months using standard guidelines for the Keto group vs standard guidelines modified by nutrigenetic advice for the low-Glycaemic Index nutrigenetic diet (lowGI/NG) group. Results:After 24?weeks, the keto group lost more weight: -?26.2?±?3.1?kg vs -?23.5?±?6.4?kg (p?=?0.0061). However, at 18-month follow up, the subjects in the low-GI nutrigenetic diet had lost significantly more weight (-?27.5?±?8.9?kg) than those in the ketogenic diet who had regained some weight (-?19.4?±?5.0?kg) (p?

SUBMITTER: Vranceanu M

PROVIDER: S-EPMC7513277 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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A comparison of a ketogenic diet with a LowGI/nutrigenetic diet over 6 months for weight loss and 18-month follow-up.

Vranceanu Maria M Pickering Craig C Filip Lorena L Pralea Ioana Ecaterina IE Sundaram Senthil S Al-Saleh Aseel A Popa Daniela-Saveta DS Grimaldi Keith A KA

BMC nutrition 20200924

<h4>Background</h4>Obesity and its related metabolic disturbances represent a huge health burden on society. Many different weight loss interventions have been trialled with mixed efficacy, as demonstrated by the large number of individuals who regain weight upon completion of such interventions. There is evidence that the provision of genetic information may enhance long-term weight loss, either by increasing dietary adherence or through underlying biological mechanisms.<h4>Methods</h4>The inve ...[more]

PMID: 32983551

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Dataset Information

A comparison of a ketogenic diet with a LowGI/nutrigenetic diet over 6?months for weight loss and 18-month follow-up.

Publications

A comparison of a ketogenic diet with a LowGI/nutrigenetic diet over 6 months for weight loss and 18-month follow-up.

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