Ontology highlight
ABSTRACT:
SUBMITTER: Yoshida S
PROVIDER: S-EPMC7515558 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Yoshida Sakiko S Duong Connie C Oestergaard Michael M Fazio Michael M Chen Cathy C Peralta Rachael R Guo Shuling S Seth Punit P PP Li Yueju Y Beckett Laurel L Nitin Nitin N Satake Noriko N
Nanomedicine : nanotechnology, biology, and medicine 20191126
Neuroblastoma (NB) is the most common extracranial solid tumor in children. The outcomes for aggressive forms of NB remain poor. The aim of this study was to develop a new molecular-targeted therapy for NB using an antisense oligonucleotide (ASO) and superparamagnetic iron oxide (SPIO) nanoparticles (NPs), as a delivery vehicle, targeting the transcription regulator MAX dimerization protein 3 (MXD3). We previously discovered that MXD3 was highly expressed in high-risk NB, acting as an anti-apopt ...[more]